Assessment of Periodontal Disease Status, and Tooth Loss in Colorectal Cancer Patients: a Case-Control Study

Pages 32-39

Nikolaos Andreas Chrysanthakopoulos^1,* and Vassiliki Vazintari²

¹Specialized in Clinical Oncology, Cytology and Histopathology, Department of Pathological Anatomy, Medical School, University of Athens, Athens, Greece; ²Registrar in Pathology, Ilioupoli Health Centre-NHS of Greece

Abstract: Background/Objectives: There are known associations between Periodontal Disease (PD) and Colorectal Cancer (CRC), however, knowledge on the connections existing between the two diseases are not fully understood. The aim of the current research was to assess the possible differences regarding the periodontal condition and tooth loss between individuals suffering from localized CEC and healthy ones.

Materials and Methods:The study size consisted of 130 individuals suffered from CRC and 290 matching healthy controls. The participants completed a standardized health questionnaire and clinically examined. PD status was defined by assessment of probing pocket depth (PPD), clinical attachment los (CAL), plaque index (PlI), gingival in dex (GI), and bleeding on probing (BOP). The number of missing teeth was also estimated. Univariate and logistic regression models were applied to assess the possible differences between CRC patients and healthy individuals.

Results: CRC patients showed worst periodontal parameters such as PPD (p=0.048, OR=1.452, 95% CI=1.032 2.779), and CAL (p=0.022, OR=1.763, 95% CI=1.085-2,867) after adjustment for smoking, socio-economic and educational status, compared with healthy individuals.

Keywords: Colorectal cancer, periodontal disease, adults, risk factors.